Armed
Forces Institute of Pathology. Poster Board Number: 178
Brett D Owens, MD, American Academy of Orthopaedic Surgeons 1999 Annual
Meeting Poster Exhibits
BIRBECK
GRANULES, EM - Tennis racket shaped structures found
in Langerhan's cells in histiocytosis X (Langerhan's cell histiocytosis)
which includes eosinophilic granuloma, Letterer-Siwe disease and Hand-Schuller-Christian
disease.
Eosinophilic
granuloma. Eosinophilic granuloma is considered
to be a localized form of histiocytosis X or Langerhans' cell histiocytosis,
a process which predominantly involves infants or children. It falls on
the more benign aspect of a spectrum of disease which includes Hand-Schuller-Christian
and Letterer-Siwe syndromes. The former is a chronic disseminated histiocytosis
classically presenting with a triad of lytic skull lesions, proptosis,
and diabetes insipidus. Letterer-Siwe syndrome is an acute virulent histiocytosis
which can rapidly lead to death secondary to bone marrow and vital organ
infiltration. In general, older patients such as the one presented here
tend to have more localized disease with a better prognosis. DJO
Eosinophilic
Granuloma of the Atlas Héctor R. Malvárez,
MD, Rubén A. Maenza, MD, Carlos Tello, MD, Ernesto Bersusky, MD,
Enrique Reina, MD, and Carlos Mounier, MD Buenos Aires, Argentina. GICD
Eosinophilic
granuloma, Letterer-Siwe disease and Hand-Schuller- Christian disease were
grouped together under the heading "Histiocytosis X" by Lictenstein in
1953. While all of these entities have the characteristic histiocytes in
common, the clinical spectrum varies widely. In recent years, the pulmonary
form of the disease, historically called "eosinophilic granuloma" has been
considered separately and the term "pulmonary Langerhans cell granulomatosis"
proposed to recognize the key histologic feature.
Histiocyte
SocietyAn International Community Dedicated To Research
And Treatment
The Histiocyte Society was founded in 1985 to promote the study of the
histiocyte and histiocyte-relateddisorders. Membership has grown
to over 200 physicians, nurses and scientists.
Histiocytosis
and Children.Histiocytosis is a mysterious and sometimes
fatal disease that affects about 1000 people in the U.S. each year, many
of them young children.1998 Colorado HealthNet
Histiocytosis
X or Langerhans Cell Histiocytosis.By: Dr. Mauro
Goldbaum, Fellow at Manhattan Eye, Ear and Throat Hospital, Post-Graduate
at The Department of Ophthalmology, Medical School of University of Sao
Paulo, Brazil. ``Histiocytosis X was a term proposed by Lichtenstein in
1952 to embrace three disorders characterized by accumulation of histiocytes
in different tissues: eosinophilic granuloma, and-Schuller-Christian syndrome,
and Letterer-Siwe disease. Since then several other disorders havebeen
added to the initial group. As all these disorders have similar clinical
features and are....``
Histiocytosis
Xoccurs in three
manifestations of increasing severity: Eosinophilic Granuloma, Hand-Schuller-Christian
Disease and Letterer-Siwe disease. All include the same histological characteristics.
Monocyte-macrophage origins and Langerhans Granules (but Letterer-Siwe
does not contain Giant cells). The characteristic appearance of histiocytosis
X in the skull is geographical, like colouring the countries on a map of
europe. Differential (bevel appearance) involvement of the inner and outer
table helps distinguish it. Some sources suggest that skeletal involvement
elsewhere can have a beveled edge, resulting in a thick rim of lower density
bone around the lytic area.
Histiocytosis-X
-Histiocytosis-X
(Birbeck granules in Langerhan cell), from skin biopsy Electron Microscopy
laboratory-Pathology Women's College Hospital.
Langerhan's
Cell Disease (Histiocytosis X). Electron Microscopy
of Paraffin Embedded Tissue. T. Wallace, M.D., N. Grossl, M.D., V. Murrah,
DDS; S. Muller, DDS.Department of Pathology Emory University School of
Medicine Atlanta, GA., Katherine Chorneyko, M.D. Department of Pathology
McMaster University Medical Center Hamilton, Ontario
Langerhans'
Cell Histiocytosis with Thyroid Involvement Masquerading as Thyroid Carcinoma.
Wei-Shu Wang, Jin-Hwang Liu, Tzeon-Jye Chiou, Ruey-Kuen Hsieh, Chueh-Chuan
Yen and Po-Min Chen. Division of Medical Oncology, Department of Medicine,
and National Yang-Ming University School of Medicine, Taipei, Taiwan. Japanese
Journal of Clinical Oncology 1997 Pages 180-184
Langerhans
Cell Histiocytosis. by Maria A Selim, M.D., Associate
Director of Dermatopathology, Pathology Department, Duke University Medical
Center. eMedicine.com
Langerhan's
Cell Histiocytosis: Langerhans' Cell Histiocytosis (formerly
referred to as Histiocytosis X) comprises a group of reticuloendothelioses
which are not truly neoplasms but which are characterized by a varied and
abnormal proliferation of histiocytes. The spectrum of clinical and pathologic
entities included in this diverse group of diseases include isolated bone
involvement (solitary and multifocal, Eosinophilic Granulomas), the relatively
benign disseminated disease ((Hand -Schuller-Christian disease), and the
highly malignant form (Letterer-Siwe disease). Musculoskeletal manifestations
occur 78% of the time. With skeletal involvement, there is a predilection
for marrow involvement with the flat bones of the skull and ileum being
the most frequently involved [Collier, Fogelman and Rosenthall, Skeletal
Nuclear Medicine, 1996].
Letterer-Siewe
lymph node Photo. 1st Institute of Pathology and
Experimental Cancer Research, Semmelweis University of Medical Sciences,
Budapest, Hungary. Pathology Pathway
Rosai-Dorfman
Disease (Extranodal Sinus Histiocytosis) in a Patient With HIV Brian
P. Perry, MD, Cynthia M. Gregg, MD, Division of Otolaryngology-Head and
Neck Surgery; Sarah Myers, MD, Department of Dermatology; Scott Lilly,
MD, Karen P. Mann, PhD, MD, Department of Hematology-Oncology; Victor Prieto,
MD, Depart-ment of Pathology, Duke University Medical Center, Durham, North
Carolina.
Sinus
histiocytosis- Photo1st Institute of Pathology and Experimental
Cancer Research, Semmelweis University of Medical Sciences, Budapest, Hungary.
Pathology Pathway.
Sinus
histiocytosisPhoto. 1st Institute of Pathology and Experimental
Cancer Research, Semmelweis University of Medical Sciences, Budapest, Hungary.
Pathology Pathway
Supporting
Times -The official newsletter of the Histiocytosis
Support Group UK. Support for Langerhan Cell Histiocytosis, Haemophagacitic
Lymphohistiocytosis, Rosai Dorfmans Disease and all other forms of histiocytosis
The Histiocytosis
Association of AmericaAn International Partnership
in search of a cure This is the original histiocytosis web site. In addition
to providing information about the disease and its treatments, this site
provides Lounges where people can discuss their involvement with all aspects
of histiocytosis. Histiocytosis Association of America Jeffrey M. Toughill,
President (president@histio.org) 302 North Broadway Pitman, NJ 08071 USA