ANTIPHOSPHOLIPID (HUGHES') SYNDROME. A treatable cause of
recurrent pregnancy loss. This syndrome was first described by Hughes in
1983. It is an important cause of thrombotic disease, both venous and arterial
(especially recurrent cerebral ischemic attacks). Other features include
mild thrombocytopenia, chorea, heart valve disease, livedo reticularis,
and most commonly, recurrent pregnancy loss.
antibodies ``Many previous studies have suggested that the
most useful immunological investigations in terms of both yield and future
treatment prospects are those for antiphospholipid antibodies (APA`s),
namely anticardiolipin antibodies (ACA) and lupus
Antibody Syndrome (Lupus-Like Syndrome) and Pregnancy
By Denise Chism, R.N., M.S.N., P.N.N.P. Antiphospholipid antibody
syndrome, also known as lupus-like syndrome, occurs in women with or without
autoimmune disease. Women with this disorder have certain positive markers
in the blood known as lupus anticoagulant and anticardiolipid antibodies
and have frequent pregnancy loss or fetal death as a result......... 1998
by Denise M. Chism and the RGA Publishing Group. WebMD Inc.
Antibody Syndrome. by Sara Marder, M.D. Instructor and Fellow
in Maternal and Fetal Medicine Department of Obstetrics and Gynecology
Yale University School of Medicine
Standardization Laboratory (APLS) web site. Welcome
to the Antiphospholipid Standardization Laboratory (APLS) web site. Internationally
recognized for establishing and standardizing the anticardiolipin (aCL)
ELISA, we are the primary reference laboratory for aCL testing. Our
test standards are used by most large commercial testing facilities
and universities in the USA as well in Europe and Asia...........
SYNDROME (APLS). A phospholipid is a fat (lipid) that
contains phosphorous. It undergoes hydrolysis , meaning it splits into
fatty acids, glycerin and a nitrogen compound by the addition of water.
The antiphospholipid syndrome (A.P.L.S.) is defined by antiphospholipid
antibodies and blood clots forming in blood vessels, recurrent pregnancy
loss, or a decrease in the number of blood platelets. 1999 American Heart
Syndrome Antiphospholipid syndrome (APS) is characterized
by the following: venous or arterial thrombosis--a condition where clots,
called thrombi, form in the blood vessels; recurrent miscarriages--the
repeated loss of the fetus in pregnancies; and thrombocytopenia--a
low number of blood platelets that can lead to bleeding, seen as
bruising and tiny red dots on the skin. Medical College of Wisconsin.
Syndrome In the 1950's it was discovered that approximately
10% of patients with systemic lupus erythematosus had circulating lupus
anticoagulant which falls under the classification of antiphospholipid
antibodies. The presence of these antibodies was associated with an increased
risk of thrombosis
Syndrome by Sara Marder, M.D. Instructor
and Fellow in Maternal and Fetal Medicine Department of Obstetrics
and Gynecology Yale University School of Medicine. Hygeia
Foundation for Perinatal Loss and Bereavement, Inc.
syndrome. Antiphospholipid syndrome (APS) is the name given
to a disease which involves the immune system. Normally antibodies are
good and they help fight germs or viral infections from outside, however,
occasionally the immune system makes the wrong kind - a type that acts
against the body itself. These unusual auto-antibodies in APS are detected
by a blood test and when they are present make a person more likely to
get specific problems. Women's Health, UK.
SyndromeAntiphospholipid antibodies are a group of antibodies
that are detected in the blood of some patients. Patients
with Antiphospholipid antibodies can have a variety of conditions, including:
autoimmune diseases (such as lupus), infections, lymphoproliferative disorders
(certain forms of cancer). They can also be present in patients who have
had long-term therapy with certain medications such as procainamide (heart
medication) and chlorpromazine (psychiatric medication). There are 2 antiphospholipids
that are most associated with SLE AntiCardiolipin and Lupus Anticoagulant
. Those 2 are what will be focused on here. In SLE and SLE-like conditions,
antiphospholipids are thought to occur in between 18 - 61% of the patients.
In the general population, the prevalence is 0 - 14%. So, although antiphospholipids
are not listed as a criteron for diagnosis, the presence of them would
give weight to an existing diagnosis, or certainly point toward SLE as
a consideration. 1999 Management Techniques Incorporated.
Antibodies and Pregnancy Problems Jeffrey S. Ginsberg,
MD Director, Thromboembolism Unit, Chedoke-McMaster Hospitals
Associate Professor, McMaster University, Hamilton. Originally published
Lupus Canada Bulletin, Volume5 No. 2, Fall 1995
Antibodies Ernie Stacey. Head Technologist, Hematology
Section, Dept. of Laboratory Medicine University Hospital, Vancouver, B.C.
& Dana V. Devine Ass't Professor of Pathology, University of
B.C. Scientist, Canadian Red Cross, Blood Transfusion Service Originally
published Lupus Canada Bulletin, Volume 3 No. 1, Spring 1993
Laboratories - Antiphospholipid Syndrome `` ANTIPHOSPHOLIPID
ANTIBODY SYNDROME (APS) is a term used to describe the association between
recurrent clinical events such as thrombosis (arterial or venous), thrombocytopenia,
or fetal loss and the presence of a persistent antiphospholipid antibody.
Other clinical conditions associated with the syndrome include stroke,
transient ischemic attack, livedo reticularis, migraine, epilepsy, and
heart valve disease4. The syndrome is termed "primary" if there is no accompanying
autoimmune disease and "secondary" if the patient also has systemic lupus
erythematosus (SLE) or an autoimmune disorder. Certain infectious diseases
and drugs may also result in the formation of antiphospholipid antibodies
which do not appear to be associated with clinical complications and do
not require therapy..... ``
Place -- Antiphospholipid Syndrome and Hepatitis C
Antiphospholipid antibody is an auto-antibody made against one's own normal
body chemicals. This antibody, traditionally associated with rheumatic
autoimmune diseases such as lupus, has been found in hepatitis C patients
showing high levels of the antibody...... Lynn
Memorial Health Care - APLS. The Antiphospholipid Syndrome
by Vernon W. Berglund, M.D., Rheumatologist, North Memorial Health Care.
``The antiphospholipid syndrome (APS) is characterized primarily by recurrent
arterial and/or venous thrombosis in the setting of elevated titers of
antibodies directed against phospholipid-binding plasma proteins, most
notably beta 2- glycoprotein I (beta 2-GPI). Recurrent pregnancy loss and
thrombocytopenia are also rather common manifestations in this syndrome
with a number of less common features including migraine headache, cardiac
valvular disease, livedo reticularis, leg ulcers, myelopathy, and chorea.
and pathogenesis of antiphospholipid antibodies C.M.
Celli1 and A.E. Gharavi2. 1Departamento de Bioquímica, Instituto
de Química, Universidade de São Paulo, São Paulo,
SP, Brasil 2Section of Rheumatology, Department of Medicine, Louisiana
State University Medical Center, New Orleans, LA, USA. Braz J Med Biol
Res, June 1998, Volume 31(6) 723-732
Thrombogenic Mechanism Jacob H. Rand, Xiao-Xuan Wu,
Harry A.M. Andree, Charles J. Lockwood, Seth Guller, Jonathan Scher, Peter
C. Harpel. The New England Journal of Medicine -- July 17, 1997 --
Vol. 337, No. 3
Antiphospholipid Syndrome Hajime Toyoshima, M.D., Ph.D.,
Peter P. Toth, M.D., Ph.D. and Mark A. Graber, M.D. Department of Family
Medicine University of Iowa. Family Practice Handbook,
3rd Edition, Chapter 6
antiphospholipid syndrome(Nieren Hochdruckkrh 1995
(24) 672 - 677). Antiphospholipid antibodies can be detected in laboratory
by measurement of lupus anticoagulant and anticardiolipin antibodies. The
linkage between antiphospholipid antibodies and vascular thrombosis, thrombocytopenia
and recurrent fetal loss in patients with lupus erythematosus (SLE) is
known since long time ago. In the last years this connection has been detected
in patients without SLE too and the term of antiphospholipid syndrome (APS)
was coined.....W. Habscheid:
Antiphospholipid SyndromeEdited by Ronald A. Asherson,
Ricard Cervera, Jean-Charles Piette, and Yehuda Shoenfeld. 339 pp., illustrated.
Boca Raton, Fla., CRC Press, 1996. $149.95. ISBN 0-8493-9423-6
ITALIAN REGISTRY OF ANTIPHOSPHOLIPID ANTIBODIESGuido Finazzi,
for the members of the Registry. Correspondence: Prof. Antonio Girolami,
Institute of Medical Semeiotics, via Ospedale 105, 35100 Padua, Italy.
Tel. international +39.49.8213012. Fax international +39.49.657391.